WP-1034

WP-1034 is a JAK-STAT inhibitor with proapoptotic and antileukemic activity in acute myeloid leukemia (AML) . WP-1034 blocks activation of Stat 3 and 5. WP-1034 induces cell cycle arrest and triggers apoptosis. WP-1034 can be used for AML research[1].

Product Specifications

CAS Number

[857064-42-7]

UNSPSC

12352005

Target

Apoptosis; Caspase; JAK; PARP; STAT

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(N[C@@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=CC=C([N+]([O-])=O)C=C2

Molecular Formula

C18H15N3O3

Molecular Weight

321.33

References & Citations

[1]1. Faderl S, et al. WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML) . Anticancer Res. 2005 May-Jun;25 (3B) :1841-50.