WP-1034
WP-1034 is a JAK-STAT inhibitor with proapoptotic and antileukemic activity in acute myeloid leukemia (AML) . WP-1034 blocks activation of Stat 3 and 5. WP-1034 induces cell cycle arrest and triggers apoptosis. WP-1034 can be used for AML research[1].
Product Specifications
CAS Number
857064-42-7
UNSPSC
12352005
Target
Apoptosis; Caspase; JAK; PARP; STAT
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N[C@@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=CC=C([N+]([O-])=O)C=C2
Molecular Formula
C18H15N3O3
Molecular Weight
321.33
References & Citations
[1]1. Faderl S, et al. WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML) . Anticancer Res. 2005 May-Jun;25 (3B) :1841-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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