CH4933468
CH4933468 is a thiohydantoin derivative, shows androgen receptor (AR) pure antagonist activity in vitro. CH4933468 inhibits AR-mediated transactivation and proliferation of LNCaP and LNCaP-BC2 cells. CH4933468 can be used for castration-resistant prostate cancer (CRPC) research[1].
Product Specifications
CAS Number
[875055-92-8]
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(CCCN(C(N1C2=CC=C(C#N)C(Cl)=C2)=S)C(C)(C)C1=O)(N)=O
Molecular Formula
C15H17ClN4O3S2
Molecular Weight
400.90
References & Citations
[1]1. Kawata H, et al. Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291. Prostate. 2011 Sep;71 (12) :1344-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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