CGP52608

CGP52608 is a selective agonist for the RZR/ROR receptor, known for its anti-tumor activity, and has almost no affinity for the cell surface G-protein coupled melatonin receptor. CGP52608 can inhibit the growth of mouse 16/C breast cancer cells. CGP52608 can induce the formation of vesicles in diatoms[1][2].

Product Specifications

CAS Number

[87958-67-6]

UNSPSC

12352005

Target

Melatonin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Smiles

C=CCN1/C(SCC1=O)=N\NC(NC)=S

Molecular Formula

C8H12N4OS2

Molecular Weight

244.34

References & Citations

[1]S T Tslm, et al. CGP 52608-induced cyst formation in dinoflagellates: possible involvement of a nuclear receptor for melatonin. J Pineal Res. 1996 Sep;21 (2) :101-7.|[2]Katarzyna Winczyk, et al. Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells. Neuro Endocrinol Lett. 2006 Jun;27 (3) :351-4.