Pyributicarb (Standard)

Proguanil (hydrochloride) (Standard) is the analytical standard of Proguanil (hydrochloride) . This product is intended for research and analytical applications. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784) . Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].

Product Specifications

CAS Number

[88678-67-5]

Product Name Alternative

TSH-888 (Standard)

UNSPSC

12352005

Target

Cytochrome P450; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

S=C(OC1=CC=CC(C(C)(C)C)=C1)N(C2=NC(OC)=CC=C2)C

Molecular Formula

C18H22N2O2S

Molecular Weight

330.44

References & Citations

[1]Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May;35 (5) :728-33.|[2]Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280 (3) :77-87.