STA-9584

STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin. STA-9584 exhibits potent antitumor activity in mouse xenograft model by selectively targeting microvasculature at both the center and periphery of tumors. STA-9584 can be used for research in prostate and breast cancer[1].

Product Specifications

CAS Number

[906481-23-0]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NC1=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)ON=C2)=CC=C1OC)[C@@H](N)CC4=CC=CC=C4.Cl

Molecular Formula

C28H30ClN3O6

Molecular Weight

540.01

References & Citations

[1]Foley KP, et al. The vascular disrupting agent STA-9584 exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. J Pharmacol Exp Ther. 2012 Nov;343 (2) :529-38.