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AR-9281 (Standard)

AR-9281 (Standard) is the analytical standard of AR-9281. This product is intended for research and analytical applications. AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].

Product Specifications

CAS Number

913548-29-5

UNSPSC

12352100

Target

Epoxide Hydrolase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Infection; Metabolic Disease; Cardiovascular Disease

Smiles

O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4

Molecular Formula

C18H29N3O2

Molecular Weight

319.44

References & Citations

[1]Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. |[2]Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303 (7) :H853-62.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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