LY164846

LY164846 is an orally active cephalosporin. LY164846 is highly sensitive to Haemophilus influenzae (including Ampicillin (HY-B0522) -resistant strains) and Moraxella catarrhalis (with MIC90 ≤ 4 μg/mL) . LY164846 is generally sensitive to Methicillin (HY-121544) -resistant Staphylococcus aureus and Streptococcus (except Enterococcus) (with MIC90: 0.25 - 8 μg/mL), and moderately sensitive to anaerobic bacteria. LY164846 has MBC/MIC ratio to Haemophilus influenzae of ≤ 2, showing bactericidal activity. LY164846 can be used for research on respiratory and skin infections[1][2].

Product Specifications

CAS Number

[92218-37-6]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CSC4=CC=CC=C43)=O)C1=O)O

Molecular Formula

C18H17N3O4S2

Molecular Weight

403.48

References & Citations

[1]Lauderdale BL, et al. In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates. Antimicrob Agents Chemother. 1986 Apr;29 (4) :560-4. |[2]Jones RN, et al. LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks. Antimicrob Agents Chemother. 1986 Mar;29 (3) :530-4.