AF3442
AF3442 is a potent and selective mPGES-1 inhibitor (IC50 = 0.06 μM) which reduces monocyte PGE2 generation also in the presence of plasma proteins. AF3442 shows selectivity over other prostanoids (TXB2, PGF2α and 6-keto-PGF1α) . AF3442 can be used for research in analgesia[1].
Product Specifications
CAS Number
[924636-93-1]
UNSPSC
12352005
Target
PGE synthase
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3)C4=CC=CC=C4C(F)(F)F
Molecular Formula
C22H17F3N2O
Molecular Weight
382.38
References & Citations
[1]Bruno A, et al. Effects of AF3442 [N- (9-ethyl-9H-carbazol-3-yl) -2- (trifluoromethyl) benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro. Biochem Pharmacol. 2010 Apr 1;79 (7) :974-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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