JNJ-37822681 (dihydrochloride) (Standard)

JNJ-37822681 (dihydrochloride) (Standard) is the analytical standard of JNJ-37822681 (dihydrochloride) . This product is intended for research and analytical applications. JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1][2].

Product Specifications

CAS Number

[2108806-02-4]

UNSPSC

12352100

Target

Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

FC(C1=NN=C(NC2CCN(CC3=CC=C(F)C(F)=C3)CC2)C=C1)(F)F.Cl.Cl

Molecular Formula

C17H19Cl2F5N4

Molecular Weight

445.26

References & Citations

[1]Langlois X, et, al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342 (1) :91-105.|[2]de Waal EJ, et, al. Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics. J Appl Toxicol. 2014 Sep;34 (9) :974-92.