UK122 (hydrochloride)
UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM) . UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].
Product Specifications
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.43
Smiles
N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N.Cl
Molecular Formula
C17H14ClN3O2
Molecular Weight
327.76
References & Citations
[1]Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6 (4) :1348-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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