DPC423 (free base)
DPC423 free base is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis[1][2].
Product Specifications
CAS Number
209957-47-1
UNSPSC
12352005
Target
Factor Xa; Kallikrein; Ser/Thr Protease; Thrombin
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC(C(F)(F)F)=NN1C2=CC=CC(CN)=C2)NC3=CC=C(C4=CC=CC=C4S(=O)(C)=O)C=C3F
Molecular Formula
C25H20F4N4O3S
Molecular Weight
532.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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