CGP-74514 (dihydrochloride)

CGP-74514 dihydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50=25 nM) . CGP-74514 dihydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 dihydrochloride is promising for research of bladder cancer[1][2].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; CDK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CCN1C2=NC(N[C@@H]3CCCC[C@@H]3N)=NC(NC4=CC(Cl)=CC=C4)=C2N=C1.Cl.Cl

Molecular Formula

C19H26Cl3N7

Molecular Weight

458.82

References & Citations

[1]Furet P, et al. Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14 (5) :403-9.|[2]Imbach P, et al. 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9 (1) :91-6.