Ischemin
Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia) [1].
Product Specifications
CAS Number
1357059-00-7
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; MDM-2/p53
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cardiovascular Disease
Purity
99.8
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(/N=N/C2=CC(C)=C(O)C=C2N)=C(C)C=C1C)(O)=O
Molecular Formula
C15H17N3O4S
Molecular Weight
335.38
References & Citations
[1]Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18 (4) :531-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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