NGD 98-2 (hydrochloride)

NGD 98-2 hydrochloride is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist

Product Specifications

CAS Number

[1780390-58-0]

UNSPSC

12352005

Target

CRFR

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

CC1=NC(NC(CC)CC)=C(N=C1C2=CC=C(C=C2OC)OC(F)(F)F)OC.Cl

Molecular Formula

C19H25ClF3N3O3

Molecular Weight

435.87

References & Citations

[1]Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N- (1-ethylpropyl) -[3-methoxy-5- (2-methoxy-4-trifluoromethoxyphenyl) -6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2) : an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23;54 (12) :4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. PMID: 21618986.|[2]Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8 (9) :e73749. doi: 10.1371/journal.pone.0073749. PMID: 24040053; PMCID: PMC3765344.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported