AZD 9272 (Standard)

AZD 9272 (Standard) is the analytical standard of AZD 9272. This product is intended for research and analytical applications. AZD 9272 is a brain penetrant mGluR5 antagonist.

Product Specifications

CAS Number

[327056-26-8]

UNSPSC

12352100

Target

MGluR; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

N#CC1=CC(F)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1

Molecular Formula

C14H6F2N4O

Molecular Weight

284.22

References & Citations

[1]Swedberg MD, et al. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J Pharmacol Exp Ther. 2014 Aug;350 (2) :212-22.|[2]Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22 (22) :6974-9.