6bK (formate)
6bK formate is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK formate increases circulating insulin in high-fat-fed mice. Acute administration of 6bK formate enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. 6bK formate can be used for type 2 diabetes research[1].
Product Specifications
UNSPSC
12352005
Target
IDE
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Purity
97.02
Smiles
O=CO.O=C(N[C@@H](C(NCCCC[C@H]1C(N)=O)=O)CC(C=C2)=CC=C2C(C3=CC=CC=C3)=O)[C@@H](NC([C@@H](NC(/C=C/C(N1)=O)=O)CCCCN)=O)CC4CCCCC4
Molecular Formula
C42H57N7O9
Molecular Weight
803.94
References & Citations
[1]Costes S, Butler PC. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?. Cell Metab. 2014;20 (2) :201-203.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Tyrosinase (T311), CF405S conjugate, 0.1mg/mL
Prolactin Receptor (B6.2), CF640R conjugate, 0.1mg/mL
Cytokeratin 14 (KRT14) (Squamous Cell Marker) (KRT14/2375), CF594 conjugate, 0.1mg/mL
