NB-216
NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM) . NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM) . NB-216 can be used for the study of Alzheimer's disease[1].
Product Specifications
CAS Number
[943924-04-7]
UNSPSC
12352005
Target
Beta-secretase; Cathepsin
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5
Molecular Formula
C35H45N3O4
Molecular Weight
571.75
References & Citations
[1]Lerchner A, et al. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :603-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; Cathepsin D; Cathepsin E
Curated Selection
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