NB-216
NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM) . NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM) . NB-216 can be used for the study of Alzheimer's disease[1].
Product Specifications
CAS Number
943924-04-7
UNSPSC
12352005
Target
Beta-secretase; Cathepsin
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5
Molecular Formula
C35H45N3O4
Molecular Weight
571.75
References & Citations
[1]Lerchner A, et al. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :603-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; Cathepsin D; Cathepsin E
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040029-100 1x 100 µL
Fibronectin (TV-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470158-500 1x 500 µL
Cytokeratin 17 (E3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472465-500 1x 500 µL
Ki-67 (Proliferating Cell Marker) (MKI67/2465), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details