PSB-1114 (tetrasodium)
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors[1].
Product Specifications
CAS Number
1657025-60-9
UNSPSC
12352005
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
Molecular Formula
C10H11F2N2Na4O13P3S
Molecular Weight
622.14
References & Citations
[1]El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54 (8) :2878-90.|[2]Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y2 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSM041076-01 10 µg
Recombinant Mouse Interleukin-17F/IL-17F Protein (His Tag)
Sign In for Pricing
View Details PKSM041076-02 50 µg
Recombinant Mouse Interleukin-17F/IL-17F Protein (His Tag)
Sign In for Pricing
View Details ![ZNF19 Mouse Monoclonal Antibody [Clone ID: OTI10C3]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908ad9/imageurl/cf811266.webp)
CF811266 100 µg
ZNF19 Mouse Monoclonal Antibody [Clone ID: OTI10C3]
Sign In for Pricing
View Details 
BNC472043-100 1x 100 µL
Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) (KRT16/2043R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 