UA62784

UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer[1][2].

Product Specifications

CAS Number

313367-92-9

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Kinesin; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

O=C1C2=C(C3=C1C=CC=C3)C(C4=NC=C(C5=CC=C(OC)C=C5)O4)=CC=C2

Molecular Formula

C23H15NO3

Molecular Weight

353.37

Precautions

P264-P270-P330-P501

References & Citations

[1]Tcherniuk S, et al. UA62784 Is a cytotoxic inhibitor of microtubules, not CENP-E. Chem Biol. 2011 May 27;18 (5) :631-41. |[2]Henderson MC, et al. UA62784, a novel inhibitor of centromere protein E kinesin-like protein. Mol Cancer Ther. 2009 Jan;8 (1) :36-44.