(2R,4R,6S) -Tubacin

(2R,4R,6S) -Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428) . Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) [1].

Product Specifications

CAS Number

[1350555-93-9]

UNSPSC

12352005

Target

Beta-lactamase; HDAC; Virus Protease

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Infection

Smiles

OCC(C=C1)=CC=C1[C@H](C2)O[C@@H](C3=CC=C(C=C3)NC(CCCCCCC(NO)=O)=O)O[C@H]2CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4

Molecular Formula

C41H43N3O7S

Molecular Weight

721.86

References & Citations

[1]Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18 (5) :954.