(2R,4R,6S) -Tubacin
(2R,4R,6S) -Tubacin is the 2R,4R,6S enantiomer of Tubacin (HY-13428) . Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) [1].
Product Specifications
CAS Number
[1350555-93-9]
UNSPSC
12352005
Target
Beta-lactamase; HDAC; Virus Protease
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection
Smiles
OCC(C=C1)=CC=C1[C@H](C2)O[C@@H](C3=CC=C(C=C3)NC(CCCCCCC(NO)=O)=O)O[C@H]2CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4
Molecular Formula
C41H43N3O7S
Molecular Weight
721.86
References & Citations
[1]Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18 (5) :954.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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