Momelotinib-d4 (dihydrochloride hydrate)

Momelotinib-d4 (CYT387-d4) dihydrochloride hydrate is a deuterium labeled Momelotinib (HY-10961) . Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50s of 11 nM and 18 nM, respectively. CYT387 shows much less activity against JAK3[1].

Product Specifications

CAS Number

[2056097-81-3]

Product Name Alternative

CYT387-d4 (hydrochloride hydrate)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Isotope-Labeled Compounds; JAK

Related Pathways

Apoptosis; Autophagy; Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

N#CCNC(C(C=C1)=CC=C1C2=NC(NC3=CC=C(N4C([2H])([2H])COCC4([2H])[2H])C=C3)=NC=C2)=O.Cl.O.Cl

Molecular Formula

C23H22D4Cl2N6O3

Molecular Weight

509.42

References & Citations

[1]Pardanani A, et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia, 2009, 23 (8), 1441-1445.