Momelotinib-d4 (dihydrochloride hydrate)
Momelotinib-d4 (CYT387-d4) dihydrochloride hydrate is a deuterium labeled Momelotinib. Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50s of 11 nM and 18 nM, respectively. CYT387 shows much less activity against JAK3[1].
Product Specifications
CAS Number
2056097-81-3
Product Name Alternative
CYT387-d4 (hydrochloride hydrate)
UNSPSC
12352005
Target
Apoptosis; Autophagy; Isotope-Labeled Compounds; JAK
Related Pathways
Apoptosis; Autophagy; Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#CCNC(C(C=C1)=CC=C1C2=NC(NC3=CC=C(N4C([2H])([2H])COCC4([2H])[2H])C=C3)=NC=C2)=O.Cl.O.Cl
Molecular Formula
C23H22D4Cl2N6O3
Molecular Weight
509.42
References & Citations
[1]Pardanani A, et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia, 2009, 23 (8), 1441-1445.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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