Manganese chloride (tetrahydrate), molecular biology grade, ≥99.0% (KT)

Manganese chloride (tetrahydrate), molecular biology grade, ≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.

Product Specifications

CAS Number

[13446-34-9]

Product Name Alternative

Manganese (II) chloride (tetrahydrate), molecular biology grade, ≥99.0% (KT)

UNSPSC

12352200

Hazard Statement

H301, H318, H373, H402

Target

Biochemical Assay Reagents; HDAC; Histone Acetyltransferase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Neurological Disease

Purity

99.08

Solubility

H2O : 1666.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[MnCl2?4H2O]

Molecular Formula

Cl2H8MnO4

Molecular Weight

197.91

Precautions

H301, H318, H373, H402

References & Citations

[1]Lima PD, et al. Genotoxic and cytotoxic effects of manganese chloride in cultured human lymphocytes treated in different phases of cell cycle. Toxicol In Vitro. 2008 Jun;22 (4) :1032-7.|[2]Guo Z, et al. Manganese chloride induces histone acetylation changes in neuronal cells: Its role in manganese-induced damage. Neurotoxicology. 2018 Mar;65:255-263.|[3]Doyle D, et al. Inhibition of cell differentiation by manganese chloride in micromass cultures of mouse embryonic limb bud cells. Toxicol In Vitro. 2002 Apr;16 (2) :101-6. |[4]Elbetieha A, et al. Effects of long-term exposure to manganese chloride on fertility of male and female mice. Toxicol Lett. 2001 Mar 8;119 (3) :193-201.|[5]Dodd CA, et al. Basal Ganglia accumulation and motor assessment following manganese chloride exposure in the C57BL/6 mouse. Int J Toxicol. 2005 Nov-Dec;24 (6) :389-97.|[6]Dorman DC, et al. Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J Appl Toxicol. 2000 May-Jun;20 (3) :179-87.|[7]Khan KN, et al. Toxicity of subacute intravenous manganese chloride administration in beagle dogs. Toxicol Pathol. 1997 Jul-Aug;25 (4) :344-50.