Pifithrin-μ (Standard)

Pifithrin-μ (Standard) is the analytical standard of Pifithrin-μ. This product is intended for research and analytical applications. Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

Product Specifications

CAS Number

[64984-31-2]

UNSPSC

12352100

Target

Autophagy; HSP; MDM-2/p53; Reference Standards

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Neurological Disease

Smiles

O=S(C#CC1=CC=CC=C1)(N)=O

Molecular Formula

C8H7NO2S

Molecular Weight

181.21

References & Citations

[1]Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2 (9) :474-9. Epub 2006 Jul 23.|[2]Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37 (1) :313-322.|[3]Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49 (2) :229-234.