Zandelisib (hydrochloride)
Zandelisib (ME-401) hydrochloride is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib hydrochloride can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib hydrochloride can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma[1].
Product Specifications
CAS Number
2839515-65-8
Product Name Alternative
ME-401 (hydrochloride) ; PWT-143 (hydrochloride)
UNSPSC
12352005
Target
Akt; PI3K
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN1CCC(C2=CC=CC=C2CC(NC3=NC(N4C5=CC=CC=C5N=C4C(F)F)=NC(N6CCOCC6)=N3)(C)C)CC1.Cl.[x]
Molecular Formula
C31H38F2N8O.xHCl
Molecular Weight
576.68 (free base)
References & Citations
[1]Kunieda K, et al. A long-lasting PI3Kδ inhibitor zandelisib forms a water-shielded hydrogen bond with p110δ and demonstrates sustained inhibitory effects. Am J Cancer Res. 2025 May 15;15 (5) :2097-2110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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