C-1311

C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1].

Product Specifications

CAS Number

[138154-39-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Mitosis; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C2=C(C=CC(O)=C2)N(C=N3)C4=C3C=CC(NCCN(CC)CC)=C14

Molecular Formula

C20H22N4O2

Molecular Weight

350.41

Precautions

P264-P270-P330-P501

References & Citations

[1]Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69 (5) :801-9.