Danegaptide-d5

Danegaptide-d5 (GAP-134-d5) is deuterium labeled Danegaptide. Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].

Product Specifications

Product Name Alternative

GAP-134-d5; ZP 1609-d5

UNSPSC

12352005

Target

Gap Junction Protein; Isotope-Labeled Compounds

Related Pathways

Cytoskeleton; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]

Molecular Formula

C14H12D5N3O4

Molecular Weight

296.33

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]John A Butera, et al. Discovery of (2S,4R) -1- (2-aminoacetyl) -4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134) 13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52 (4) :908-11.|[3]Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163 (3) :469-83.