Danicamtiv-d3

Danicamtiv-d3 (MYK-491-d3) is a deuterated labeled Danicamtiv (HY-109128) . Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].

Product Specifications

CAS Number

[2925925-82-0]

Product Name Alternative

MYK-491-d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Myosin

Related Pathways

Cytoskeleton; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=S([C@@](C1CCN(CC1)C(NC2=NOC=C2)=O)(C)F)(C3=CN(N=C3C(F)F)C([2H])([2H])[2H])=O

Molecular Formula

C16H17D3F3N5O4S

Molecular Weight

438.44

References & Citations

[1]Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707.