SPK-843

SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections[1].

Product Specifications

CAS Number

[143483-67-4]

Product Name Alternative

SPA-S-753 (free base)

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C([C@H]1[C@@](C[C@H](/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@]([C@@H](C)CCC(O)CC(C2=CC=C(NC)C=C2)=O)([H])OC3=O)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4NC(CN(C)C)=O)([H])[C@H]4O)([H])O[C@](O)(C[C@H](C[C@H](C[C@H](C[C@H](CC(C[C@H](C3)O)=O)O)O)O)O)C[C@@H]1O)NCCN(C)C

Molecular Formula

C67H103N5O19

Molecular Weight

1282.56

References & Citations

[1]Kakeya H, et al. Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis. Antimicrob Agents Chemother. 2008 May;52 (5) :1868-70.