Otaplimastat (hydrochloride)
Otaplimastat (SP-8203) hydrobromide, a matrix metalloproteinase (MMP) inhibitor, blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat hydrobromide also exhibits anti-oxidant activity. Otaplimastat hydrobromide can be used for the research of brain ischemic injury[1][2][3].
Product Specifications
CAS Number
1176758-02-3
Product Name Alternative
SP-8203 (hydrochloride)
UNSPSC
12352005
Target
IGluR; MMP
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cardiovascular Disease; Neurological Disease
Smiles
CC(N(CCCN1C(NC2=C(C=CC=C2)C1=O)=O)CCCCNCCCN3C(NC4=C(C=CC=C4)C3=O)=O)=O.Cl
Molecular Formula
C28H35ClN6O5
Molecular Weight
571.07
References & Citations
[1]Noh SJ, et, al. SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor. Pharmacol Biochem Behav. 2011 Nov;100 (1) :73-80.|[2]Kim JS, et, al. Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA) : A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study. Ann Neurol. 2020 Feb;87 (2) :233-245.|[3]Noh SJ, et, al. SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia. Pharmacol Biochem Behav. 2011 Mar;98 (1) :150-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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