Tapinarof-d5

Tapinarof-d5 (WBI-1001-d5) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice[1].

Product Specifications

CAS Number

[2748997-80-8]

Product Name Alternative

WBI-1001-d5; Benvitimod-d5; GSK2894512-d5

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor; Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC(C=C1/C=C/C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=C(C(O)=C1)C(C)C

Molecular Formula

C17H13D5O2

Molecular Weight

259.35

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Smith SH, et al. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans. J Invest Dermatol. 2017 Oct;137 (10) :2110-2119.