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Quilseconazole (Standard)

Quilseconazole (Standard) is the analytical standard of Quilseconazole. This product is intended for research and analytical applications. Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases[1].

Product Specifications

CAS Number

1340593-70-5

UNSPSC

12352100

Target

Cytochrome P450; Fungal; Reference Standards

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Smiles

O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=N3)F

Molecular Formula

C22H14F7N5O2

Molecular Weight

513.37

References & Citations

[1]Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60 (4) :2528-31.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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