Mavacamten-d7
Mavacamten-d7 (MYK461-d7) is deuterium labeled Mavacamten. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Product Specifications
Product Name Alternative
MYK461-d7; SAR439152-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Myosin
Related Pathways
Cytoskeleton; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C=C(N[C@H](C1=CC=CC=C1)C)N2)N(C2=O)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C15H12D7N3O2
Molecular Weight
280.37
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[3]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[4]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC402853-500 1x 500 µL
CD54 / ICAM-1 (15.2), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470410-500 1x 500 µL
MALT-1 (MT1/410), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNCB0017-100 1x 100 µL
Ep-CAM / CD326 (VU-1D9), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400394-500 1x 500 µL
Cytokeratin 19 (Ks19.1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742383-100 1x 100 µL
CD40 / TNFRSF5 / CD40L-Receptor (C40/2383), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681543-100 1x 100 µL
Calnexin (Endoplasmic Reticulum Marker) (CANX/1543), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details