Imarikiren (hydrochloride)

Imarikiren hydrochloride is a renin inhibitor. Imarikiren hydrochloride can be used for the study of cardiovascular and renal diseases such as hypertension, heart failure, and diabetic nephropathy by blocking the renin-angiotensin (RA) system[1].

Product Specifications

CAS Number

[1202269-24-6]

UNSPSC

12352005

Target

Renin

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

COCCCCN1C(C(N([C@H]2C[C@H](CNC2)C(N3CCOCC3)=O)CC(C)C)=O)=NC4=CC=CC=C14.Cl

Molecular Formula

C27H42ClN5O4

Molecular Weight

536.11

References & Citations

[1]Matsuno K, et al. A Randomized, Single-Center, Double-Blind, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Imarikiren in Healthy Adult Nonelderly and Elderly Male Subjects. J Clin Pharmacol. 2018 Nov;58 (11) :1516-1524.