Ifoxetine

Ifoxetine (CGP 15210G) is an inhibitor of 5-HT reuptake. Ifoxetine specifically and selectively blocks the 5-HT reuptake in the brain without affecting the 5-HT uptake processes in the periphery (blood platelets) . Ifoxetine inhibits the uptake of radiolabelled 5-HT into rat brain synaptosomes in vitro or ex vivo. Ifoxetine has antidepressant properties[1][2].

Product Specifications

CAS Number

[66208-11-5]

Product Name Alternative

CGP-15210G

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(C(C)=CC=C1)=C1O[C@H]2[C@H](CNCC2)O

Molecular Formula

C13H19NO2

Molecular Weight

221.30

References & Citations

[1]P. C. Waldmeier, et al. Ifoxetine: An Unusual 5-HT Uptake Inhibitor or an Inhibitor of 5-HT Release? Pharmacopsychiatry 1986; 19 (4) : 318-319.|[2]Delini-Stula A, et al. First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs. Int Clin Psychopharmacol. 1987 Jul;2 (3) :201-15.