D-87503

D-87503 is a potent inhibitor of PI3k/Akt/mTOR, with the IC50s of 62 nM and 0.76 μM, respectively for PI3k and Erk2. D-87503 effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3k/Akt/mTOR signaling pathway[1].

Product Specifications

CAS Number

[800394-83-6]

UNSPSC

12352005

Target

ERK; mTOR; PI3K

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

S=C(NCC=C)NC1=CC=C2C(N=C(C3=CC=C(O)C=C3)C=N2)=N1

Molecular Formula

C17H15N5OS

Molecular Weight

337.40

References & Citations

[1]Mukesh Chandra Joshi, et al. Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology. Review Curr Drug Discov Technol. 2014 Jun;11 (2) :113-26.