Preladenant (Standard)

Preladenant (Standard) is the analytical standard of Preladenant. This product is intended for research and analytical applications. Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.

Product Specifications

CAS Number

[377727-87-2]

UNSPSC

12352100

Target

Adenosine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Neurological Disease; Cancer

Smiles

NC1=NC(N(CCN2CCN(C3=CC=C(OCCOC)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN51

Molecular Formula

C25H29N9O3

Molecular Weight

503.56

References & Citations

[1]Hodgson RA, et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2- (2-furanyl) -7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent|[2]Hodgson RA, et al. Preladenant, a selective A (2A) receptor antagonist, is active in primate models of movement disorders. Exp Neurol. 2010 Oct;225 (2) :384-90.