Ponatinib (hydrochloride) (Standard)

Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride) . This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].

Product Specifications

CAS Number

[1114544-31-8]

UNSPSC

12352100

Target

Autophagy; Bcr-Abl; FGFR; PDGFR; Reference Standards; Src; VEGFR

Related Pathways

Autophagy; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Infection

Smiles

O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl

Molecular Formula

C29H28ClF3N6O

Molecular Weight

569.02

References & Citations

[1]O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16 (5), 401-412.|[2]Gover-Proaktor A, et al. Ponatinib reduces viability, migration, and functionality of human endothelial cells. Leuk Lymphoma. 2017 Jun;58 (6) :1455-1467.|[3]Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47 (6) :436-445.