Ponatinib (hydrochloride) (Standard)
Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride) . This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
Product Specifications
CAS Number
1114544-31-8
UNSPSC
12352100
Target
Autophagy; Bcr-Abl; FGFR; PDGFR; Reference Standards; Src; VEGFR
Related Pathways
Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection
Smiles
O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl
Molecular Formula
C29H28ClF3N6O
Molecular Weight
569.02
References & Citations
[1]O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16 (5), 401-412.|[2]Gover-Proaktor A, et al. Ponatinib reduces viability, migration, and functionality of human endothelial cells. Leuk Lymphoma. 2017 Jun;58 (6) :1455-1467.|[3]Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47 (6) :436-445.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC472853-500 1x 500 µL
CD54 / ICAM-1 (15.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041948-500 1x 500 µL
Cytokeratin 10 (Suprabasal Epithelial Marker) (KRT10/1948R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details