ATPγS (tetralithium salt)

ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis[1][2][3][4][5].

Product Specifications

CAS Number

[93839-89-5]

Product Name Alternative

Adenosine-5'-O- (3-thiotriphosphate) (tetralithium salt) ; Adenosine 5'-[γ-thio]triphosphate (tetralithium salt)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Eukaryotic Initiation Factor (eIF) ; P2Y Receptor

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 75 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O[C@H](COP(OP(OP(O[Li])(O[Li])=S)(O[Li])=O)(O[Li])=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2

Molecular Formula

C10H12Li4N5O12P3S

Molecular Weight

546.98

Precautions

H315, H319, H335

References & Citations

[1]Matthew L Peck, et al. Adenosine 5'-O- (3-thio) triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9 (10) :1180-7.|[2]Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202 (1) :47-55.|[3]Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294 (2) :L319-24.|[4]Ortal Danino, et al. ATP-γ-S- (α, β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460 (2) :446-50. |[5]J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29 (33) :7666-76.