PACOCF3 (Standard)

PACOCF3 (Standard) is the analytical standard of PACOCF3. This product is intended for research and analytical applications. PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].

Product Specifications

CAS Number

[141022-99-3]

UNSPSC

12352100

Target

Phospholipase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

CCCCCCCCCCCCCCCC(C(F)(F)F)=O

Molecular Formula

C17H31F3O

Molecular Weight

308.42

References & Citations

[1]E J Ackermann, et al. Inhibition of macrophage Ca (2+) -independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270 (1) :445-50. |[2]C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74 (8) :447-51.