P-1075 (Standard)
P-1075 (Standard) is the analytical standard of P-1075. This product is intended for research and analytical applications. P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
Product Specifications
CAS Number
60559-98-0
UNSPSC
12352100
Target
Potassium Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
CCC(N/C(NC#N)=N/C1=CC=CN=C1)(C)C
Molecular Formula
C12H17N5
Molecular Weight
231.30
References & Citations
[1]Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17 (19) :5529-35.|[2]Oldenburg O, et al. P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35 (9) :1035-42.|[3]Gross ER, et al. GSK3beta inhibition and K (ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. Basic Res Cardiol. 2007 Jul;102 (4) :341-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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