BCH (Standard)
BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].
Product Specifications
CAS Number
[20448-79-7]
UNSPSC
12352100
Target
Apoptosis; Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
O=C(C1(N)C(C2)CCC2C1)O
Molecular Formula
C8H13NO2
Molecular Weight
155.20
References & Citations
[1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107 (10) :1499-1505.|[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20 (1) .|[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5 (4) :1281-94. eCollection 2015.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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