BCH (Standard)

BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].

Product Specifications

CAS Number

[20448-79-7]

UNSPSC

12352100

Target

Apoptosis; Reference Standards

Related Pathways

Apoptosis; Others

Field of Research

Cancer

Smiles

O=C(C1(N)C(C2)CCC2C1)O

Molecular Formula

C8H13NO2

Molecular Weight

155.20

References & Citations

[1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107 (10) :1499-1505.|[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20 (1) .|[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5 (4) :1281-94. eCollection 2015.