GGsTop (Standard)
GGsTop (Standard) is the analytical standard of GGsTop. This product is intended for research and analytical applications. GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model[1][2][3].
Product Specifications
CAS Number
926281-37-0
UNSPSC
12352100
Target
Reference Standards; γ-Glutamyl Transferase (GGT)
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(O)CC1=CC=CC(OP(OC)(CCC(N)C(O)=O)=O)=C1
Molecular Formula
C13H18NO7P
Molecular Weight
331.26
References & Citations
[1]Han L, et al. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase. Biochemistry. 2007 Feb 6;46 (5) :1432-47.|[2]Kamiyama A, et al. Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT) . GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity. Bioorg Med Chem. 2016 Nov 1;24 (21) :5340-5352.|[3]Tamura K, et al. GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311 (2) :G305-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR209286L3V 200 µL
Spire1 (BC094375) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details TL710291V 500 µL Each
Grem1 Rat shRNA Lentiviral Particle (Locus ID 50566)
Sign In for Pricing
View Details 