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INK4C-IN-2

INK4C-IN-2 is a p18INK4C inhibitor. NK4C-IN-2 promotes hematopoietic stem cells (HSCs) division by inhibiting INK4C and activating CDK4/6, with an ED50 of 5.21 nM. INK4C-IN-2 shows no cytotoxic to normal 32D cells, HSCs, leukemia cell lines and myeloma cell lines[1].

Product Specifications

CAS Number

6314-70-1

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

98.10

Smiles

O=C(O)C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1

Molecular Formula

C13H17NO4S

Molecular Weight

283.34

Precautions

H315, H319, H335

References & Citations

[1]Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK4; CDK6

Available Sizes

Frequently Asked Questions

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