INK4C-IN-2
INK4C-IN-2 is a p18INK4C inhibitor. NK4C-IN-2 promotes hematopoietic stem cells (HSCs) division by inhibiting INK4C and activating CDK4/6, with an ED50 of 5.21 nM. INK4C-IN-2 shows no cytotoxic to normal 32D cells, HSCs, leukemia cell lines and myeloma cell lines[1].
Product Specifications
CAS Number
[6314-70-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.10
Smiles
O=C(O)C1=CC=C(S(=O)(NC2CCCCC2)=O)C=C1
Molecular Formula
C13H17NO4S
Molecular Weight
283.34
Precautions
H315, H319, H335
References & Citations
[1]Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Available Sizes
Curated Selection
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