PF-05139962
PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity[1].
Product Specifications
CAS Number
1393712-18-9
UNSPSC
12352005
Target
MTOR
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NCC)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(CS4(=O)=O)C(CC4)=N2)C=C1
Molecular Formula
C21H27N5O4S
Molecular Weight
445.54
References & Citations
[1] Liu KK, et al. Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22 (15) :5114-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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