PBPE (hydrochloride)
PBPE hydrochloride is a derivative of tamoxifen and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively[1][2].
Product Specifications
CAS Number
262425-59-2
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Purity
99.30
Smiles
C1(OCCN2CCCC2)=CC=C(CC3=CC=CC=C3)C=C1.Cl
Molecular Formula
C19H24ClNO
Molecular Weight
317.85
References & Citations
[1]B Kedjouar, et al. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochem Pharmacol. 1999 Dec 15;58 (12) :1927-39.|[2]Florence Dalenc, et al. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. Breast Cancer Res. 2005;7 (6) :R1159-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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