PBPE (hydrochloride)

PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively[1][2].

Product Specifications

CAS Number

[262425-59-2]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Purity

99.30

Smiles

C1(OCCN2CCCC2)=CC=C(CC3=CC=CC=C3)C=C1.Cl

Molecular Formula

C19H24ClNO

Molecular Weight

317.85

References & Citations

[1]B Kedjouar, et al. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochem Pharmacol. 1999 Dec 15;58 (12) :1927-39.|[2]Florence Dalenc, et al. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. Breast Cancer Res. 2005;7 (6) :R1159-67.